Multi-objective pairwise RNA sequence alignment
نویسندگان
چکیده
منابع مشابه
Multi-objective pairwise RNA sequence alignment
MOTIVATION With an increase in the number of known biological functions of non-coding RNAs, the importance of RNA sequence alignment has risen. RNA sequence alignment problem has been investigated by many researchers as a mono-objective optimization problem where contributions from sequence similarity and secondary structure are taken into account through a single objective function. Since ther...
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MOTIVATION The calculation of reliable alignments for structured RNA is still considered as an open problem. One approach is the incorporation of secondary structure information into the optimization criteria by using a weighted sum of sequence and structure components as an objective function. As it is not clear how to choose the weighting parameters, we use multi-objective optimization to cal...
متن کاملPairwise Sequence Alignment
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متن کاملProbabalistic pairwise sequence alignment
We describe an new algorithm for visualizing an alignment of biological sequences according to a probabilistic model of evolution. The resulting data array is readily interpreted by the human eye and amenable to digital image techniques. We present examples using mRNA sequences from mouse and rat: three cytochromes and two zinc finger proteins. The underlying evolutionary model is derived from ...
متن کاملProbabilistic pairwise sequence alignment
We describe an new algorithm for visualizing an alignment of biological sequences according to a probabilistic model of evolution. The resulting data array is readily interpreted by the human eye and amenable to digital image techniques. We present examples using mRNA sequences from mouse and rat: three cytochromes and two zinc finger proteins. The underlying evolutionary model is derived from ...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2010
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btq439